The Activation Status of Rheb in Pemetrexed Treated Human Cancer

نویسندگان

  • F. T. Sakloth
  • M. H. Baumann
چکیده

each stream ecosystem may be impacted by land use and intensified human expansion. According to the fall macrobenthic results, nearly all sites saw an increase in %EPT, except for Massaponax 208 and Ni Route 1. Even though both Massaponax Creek and the Ni River are under EPA legal limits for phosphate and nitrate concentrations, the phosphate levels usually rose in summer on the Massaponax and winter for the Ni, while nitrates peak during the winter and spring for both streams. TDS increased during the summer and then declined, as precipitation rates fell. Massaponax Creek has higher TDS than the Ni, but that is reversed for TSS. Fecal coliform levels greatly decreased from summer into winter and fall, with both streams remaining under legal limits. This speaks to the recovery of the streams, resulting from repaired sewer lines and decreased erosion risks in surrounding areas specifically near Massaponax Creek. Due to the majority increase in %EPT, decreased concentration of nitrates and phosphates, and reduced fecal coliform levels, the Ni River and Massaponax Creek have generally seen an improvement in overall health.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Inhibition of miR-22 enhanced the efficacy of icotinib plus pemetrexed in a rat model of non-small cell lung cancer

Objective(s): To investigate the role of miR-22 in the efficacy of combined icotinib (BPI-2009H) and pemetrexed (LY-231514) on tumor growth and apoptosis in rats with non-small cell lung cancer (NSCLC).Materials and Methods: Rats were injected with HCC827 cells, which were transfected with anti-miR-22, followed by the treatment of BPI-20...

متن کامل

Rheb promotes cancer cell survival through p27Kip1-dependent activation of autophagy.

We previously found that the small GTPase Rheb regulates the cell-cycle inhibitor p27KIP1 (p27) in colon cancer cells by a mTORC1-independent mechanism. However, the biological function of the Rheb/p27 axis in cancer cells remains unknown. Here, we show that siRNA-mediated depletion of Rheb decreases survival of human colon cancer cells under serum deprivation. As autophagy can support cell sur...

متن کامل

بررسی میزان بیان ژن Rheb در بافت های مختلف بز سرخ جبال بارز

According to global, regional and economic importance of Jabal Barez Red goat from the cashmir production aspect and role of Rheb gene on growth, cell cycle and cancer, expression of this gene was studied in Jabal Barez Red goat for the first time. As one member of the Ras super family, Rheb is an upstream regulator of mTOR signaling pathway, which regulates the process of cell-growth, prolifer...

متن کامل

Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis.

Small GTPase Ras homologue enriched in brain (RHEB) binds and activates the key metabolic regulator mTORC1, which has an important role in cancer cells, but the role of RHEB in cancer pathogenesis has not been shown. By performing a meta-analysis of published cancer cytogenetic and transcriptome databases, we defined a gain of chromosome 7q36.1-q36.3 containing the RHEB locus, an overexpression...

متن کامل

Characteristics Determination of Rheb Gene and Protein in Raini Cashmere Goat

The aim of the present study was todeterminecharacteristics of Rheb gene and protein in Raini Cashmere goat. Comparative analyses of the nucleotide sequences were performed. Open reading frames (ORFs), theoretical molecular weights of deduced polypeptides, the protein isoelectric point, protein characteristics and three-dimensional structures was predicted using online standard softwares. The f...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2017